Ashwagandha Science ashwagandhascience.org

Research summary

Ashwagandha and Anxiety

Key takeaway

Randomized trials have examined ashwagandha and anxiety symptoms. Pooled results require caution because study results differ and evidence certainty is low.[1], [2]

What these findings do not establish

Pooled from heterogeneous trials with low rated certainty and varied extracts and doses; effect sizes differ between studies, and higher-quality trials are still needed to firmly establish the effect.[1], [2]

What the anxiety research reports

Meta-analyses of randomized controlled trials report that ashwagandha supplementation is associated with reduced anxiety symptoms compared with placebo, although the certainty of the pooled evidence has been rated low. Pooled from heterogeneous trials with low rated certainty and varied extracts and doses; effect sizes differ between studies, and higher-quality trials are still needed to firmly establish the effect.[1], [2]

Safety and medication context

NCCIH does not recommend ashwagandha for people with thyroid or autoimmune disorders or those who are about to have surgery. Discuss these conditions and any planned surgery with your healthcare professional before considering ashwagandha; supplement research does not justify changing prescribed care.[3]

Ashwagandha may interact with medicines for diabetes or high blood pressure, immunosuppressants, sedatives, anticonvulsants, and thyroid hormone medicines. Discuss possible interactions with your prescriber or pharmacist before use; do not stop, replace, or adjust prescribed medicines based on supplement information.[3]

References

  1. Does Ashwagandha supplementation have a beneficial effect on the management of anxiety and stress? A systematic review and meta-analysis of randomized controlled trials.. Phytotherapy research : PTR. 2022. Systematic review and meta-analysis View source →
  2. Effects of Ashwagandha (Withania Somnifera) on stress and anxiety: A systematic review and meta-analysis.. Explore (New York, N.Y.). 2024. Systematic review and meta-analysis View source →
  3. Ashwagandha: Usefulness and Safety. NIH National Center for Complementary and Integrative Health. Retrieved 2026-09-30. Government health fact sheet View source →

Continue from here

Use the main FAQ hub to place this research summary in context alongside dosing, forms, safety, and product-selection questions.

Browse ashwagandha FAQs →

Related